Neuropsychopharmacology Lab

Neuropsychopharmacology Lab

 

Contact Dr. Prus: 

aprus@nmu.edu

Lab location: 

New Science Facility 2305

 

Dr. Prus is the Director of the Neuropsychopharmacology laboratory. Our lab is dedicated to analyzing the neurological and behavioral effects of psychoactive drugs, particularly those used to treat illness such as depression, anxiety, and schizophrenia. Examples of recently completed or ongoing Neuropsychopharmacology lab research projects include:

  • Drug discrimination with various drugs of abuse, to determine subjective effects.
  • Effects of optogenetic (control with light) activation of dopamine neurons.
  • Use of an HPLC (High-performance liquid chromatography) apparatus to analyze neurotransmitter concentration.
  • Novel animal models for various conditions.
  • Cognitive effects of antipsychotic drugs, including assessing traditional and novel pharmacologic mechanisms.

Research in the Neuropsychopharmacology lab often becomes published in peer-reived journals or is presented at national conferences. Examples include: 

  • Prus, A. J., Mooney-Leber, S. M., Berquist, M. D., Pehrson, A. L., Porter, N. P., & Porter, J. H. (2015). The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine’s effects by the α2 adrenoceptor antagonist yohimbine. Behavioural pharmacology26(5), 489-494.

 

  • Keiser, A. A., Matazel, K. S., Esser, M. K., Feifel, D., & Prus, A. J. (2014). Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats. Experimental and clinical psychopharmacology22(6), 541.

 

  • Prus, A. J., Hillhouse, T. M., & LaCrosse, A. L. (2014). Acute, but not repeated, administration of the neurotensin NTS 1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry49, 78-84.

 

  • Prus, A. J., Schuck, C. J., Rusch, K. R., & Carey, L. M. (2014). The Discriminative Stimulus Effects of the Neurotensin NTS1 Receptor Agonist PD149163 in Rats: Stimulus Generalization Testing with Dopamine D1 and D2 Receptor Ligands. Drug development research75(2), 47-58.

 

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