Colloquium: Animal Model Use in Studying Anxiety Disorders
"Effects Of Novel Antidepressant Drugs On The Schedule-Induced Polydipsia Animal Model"
Presented by Sean Mooney-Leber, M.S. Candidate
Experimental Psychology, Northern Michigan University
When: Thursday, March 28, 2012, 1 p.m.
Where: Gries Hall, Room 301
Anxiety disorders are characterized by excessive fear about future uncertainties and can interfere with functioning. Among current medications, selective serotonin reuptake inhibitors (SSRI) and serotonin norepinephrine reuptake inhibitors (SNRI) have shown high levels of efficacy in the treatment of various anxiety disorders.
Although these treatments appear to be effective in ameliorating symptoms associated with anxiety, the therapeutic onset of action with these drugs is delayed and thus presents a significant problem with producing immediate effects. To address this issue valid animal models are necessary. However, there is no current animal model that provides a measurement of the onset of these compounds.
One putative model that has been suggested to measure the delay in these compounds is the schedule-induced polydipsia animal paradigm. The present study has sought to further characterize the effects of antidepressant drugs on schedule-induced polydipsia through the use of fluoxetine (SSRI) and duloxetine (SNRI). Fluoxetine and duloxetine both produced a robust decrease in water consumption in a time sensitive manner. Furthermore, the present findings add to previous literature suggesting that schedule-induced polydipsia is a valid animal model for measuring the onset of antidepressant drugs.
Come and learn more. This event is free and open to the public. For further information please contact the Psychology Department, 227-2935.